Article No
AT4305a
Accession Number | P11388 |
Application | WB, IHC, IF |
Article No | AT4305a |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
Clone | 100 |
Clone Type | monoclonal |
Conjugation | Unconjugated |
Description | TOP2A Antibody |
Recommended Dilution | 1:500~1000 |
Supplier | Abgent |
Entrez Gene ID | 7153 |
Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
Isotype | IgG1 k |
Notes | This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. |
Alias Names | DNA topoisomerase 2-alpha, DNA topoisomerase II, alpha isozyme, TOP2A, TOP2 |
Product Type | Antibodies Primary |
Size | 100 µg |
Source / Host | mouse |
Species Reactivity | human |
Substrate / Buffer | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
Product Page Updated | 2023-11-23T13:40:12.472Z |