Article No
AT1249a
Accession Number | O15169 |
Application | WB, IF |
Article No | AT1249a |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
Clone | 2B11 |
Clone Type | monoclonal |
Conjugation | Unconjugated |
Description | AXIN1 Antibody |
Recommended Dilution | 1:500~1000 |
Supplier | Abgent |
Entrez Gene ID | 8312 |
Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
Isotype | IgG2a k |
Notes | This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin (cadherin-associated protein), beta 1, 88kDa, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. |
Alias Names | Axin-1, Axis inhibition protein 1, hAxin, AXIN1, AXIN |
Product Type | Antibodies Primary |
Size | 100 µg |
Source / Host | mouse |
Species Reactivity | human |
Substrate / Buffer | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
Product Page Updated | 2023-11-23T13:40:12.472Z |