Article No
AT1199a
Specifications
| Accession Number | P27540 |
| Application | WB, IHC, IF |
| Article No | AT1199a |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | 3D10 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | ARNT Antibody |
| Recommended Dilution | 1:500~1000 |
| Supplier | Abgent |
| Entrez Gene ID | 405 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Isotype | IgG2a k |
| Notes | The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene. |
| Alias Names | Aryl hydrocarbon receptor nuclear translocator, ARNT protein, Class E basic helix-loop-helix protein 2, bHLHe2, Dioxin receptor, nuclear translocator, Hypoxia-inducible factor 1-beta, HIF-1-beta, HIF1-beta, ARNT, BHLHE2 |
| Product Type | Antibodies Primary |
| Size | 100 µg |
| Source / Host | mouse |
| Species Reactivity | human |
| Substrate / Buffer | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Product Page Updated | 2023-11-23T13:40:12.472Z |
