DMRT1

Article No ASJ-BC9F96
Application WB
Size 50ul

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Specifications

MW 39.5 kDa
Country Availability SE, NO, DK, FI
Clone Type polyclonal
Conjugation Unconjugated
Description Rabbit polyclonal to DMRT1
Supplier Biosite
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 134-373 of human DMRT1 (NP_068770.2).
Isotype IgG
Localization Nucleus
Notes Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation, Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm, Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1, Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes, May act as a tumor suppressor, May also play a minor role in oogenesis (By similarity).
Alias Names DMRT1, Doublesex- and mab-3-related transcription factor 1 antibody, DM domain expressed in testis protein 1, DMRT1 antibody, DMT1
Protocol WB 1:500 - 1:2000
Purification Affinity purification
Source / Host rabbit
Species Reactivity human
Storage Store at -20℃. Avoid freeze / thaw cycles.
Substrate / Buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Tissue Specificity Testis-specific, expressed in prostate cancer (at protein level).
UniProt Number Q9Y5R6
Product Page Updated 2019-04-26T06:58:35.022Z

Shipping info

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Source/Host:

rabbit rabbit

Species reactivity:

human human

Suggested protocols:

Western Blot

Western Blot