Article No
ASB-8X9IAO-0.5
Hamster Anti-Mouse CD103-LE/AF
Hamster Anti-Mouse CD103-LE/AF
Antibodies Primary
Specifications
| NCBI Number | 16407 |
| Application | FC, IHC, IP |
| Article No | ASB-8X9IAO-0.5 |
| Biosite Brand | Biosite |
| Country Availability | all |
| Clone | 2E7 |
| Clone Type | monoclonal |
| Concentration | 0.5 mg/mL |
| Conjugation | LEAF |
| Description | Hamster Anti-Mouse CD103-LE/AF |
| Supplier | Nordic Biosite |
| Format | Liquid |
| Immunogen | C57BL/6J mouse intestinal intraepithelial lymphocytes (IEL) |
| Isotype | IgG |
| Notes | CD103 is a member of the integrin series of adhesion molecules. This antigen defines a developmentally important subset of T cells, namely mucosal T cells including all IEL (intraepithelial lymphocytes) and ~20% of lamina propria T cells. Expression of CD103 is more restricted outside these mucosal organs appearing at lower levels on T cell subsets of the lymph node, dendritic epidermis, and periphery. In non-epithelial CD103+ T cells there is a bias toward expression on CD8+ cells. The 2E7 monoclonal antibody exhibits antigen immunoprecipitation patterns similar if not identical to the rat anti-mouse CD103 monoclonal antibody M290. 2E7 is reported to have signal-inducing activity in a redirected lysis assay and to costimulate IEL and CD8+ lymph node cells in conjunction with anti-TCR in vitro which runs counter to the usual inhibition of CTL by anti-integrins. This costimulatory activity is also shared by the monoclonal antibody M290. The property of costimulation is not unique to the mouse since the combination of anti-human alpha IEL plus anti-TCR will produce similar proliferation in human cells with the exception that CD8+ cells are not stimulated. |
| Alias Names | Integrin αIEL, αE integrin, ITGAE |
| Previous Article No | ASB-UGAOEX-0.5, ASB-181014, ASB-8X9IAO-0.5 |
| Product Type | Antibodies Primary |
| Shipping Information | Dry Ice |
| Size | 0.5 mg |
| Source / Host | hamster |
| Species Reactivity | mouse |
| Storage | -20°C |
| Substrate / Buffer | Phosphate buffered saline, pH 7.4 |
| Swiss-Prot No | Q60677 |
| Product Page Updated | 2024-01-11T10:51:07.446Z |
| Volume | 1.0 mL |
