Article No
ASB-DYW591-0.5
Hamster Anti-Mouse KLRG1-BIOT
Hamster Anti-Mouse KLRG1-BIOT
Antibodies Primary
Specifications
| NCBI Number | 50928, 10219 |
| Application | FC, IP, WB |
| Article No | ASB-DYW591-0.5 |
| Biosite Brand | Biosite |
| Country Availability | all |
| Clone | 2F1 |
| Clone Type | monoclonal |
| Concentration | 0.5 mg/mL |
| Conjugation | Biotin |
| Description | Hamster Anti-Mouse KLRG1-BIOT |
| Supplier | Nordic Biosite |
| Format | Liquid |
| Immunogen | IL-2-activated NK cells (A-LAK cells) from B6 (H-2b) mice |
| Isotype | IgG |
| Notes | The monoclonal antibody 2F1 reacts with mouse killer cell lectin-like receptor G1 (KLRG1; formerly known as mouse MAFA), a homodimeric member of the lectin-like type 2 transmembrane receptor family that contain characteristic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domains. These ITIMs interact with the SH2 domains of protein phosphatases such as SHP-1. The 2F1 antibody stains 30-60% of NK1.1+CD3- splenocytes, and a small fraction of T cells in all mouse strains tested (C57BL/6, BALB/c, 129/J, C3H.SW, AKR/J, SJL). Cell surface expression of KLRG1 is up-regulated by expression of MHC class I molecules. The effect of MHC class I expression is indirect, and can be mediated by interactions with class I-specific Ly49 inhibitory receptors. |
| Alias Names | MAFA, killer cell lectin-like receptor G1, mast cell function-associated-antigen |
| Previous Article No | ASB-180708, ASB-UCQOI5-0.5, ASB-DYW591-0.5 |
| Product Type | Antibodies Primary |
| Shipping Information | Ambient Temperature |
| Size | 0.5 mg |
| Source / Host | hamster |
| Species Reactivity | mouse |
| Storage | 2-8°C |
| Substrate / Buffer | Phosphate buffered saline containing < 0.1% sodium azide |
| Swiss-Prot No | O88713, Q96E93 |
| Product Page Updated | 2024-01-11T10:51:07.446Z |
| Volume | 1.0 mL |
