Article No
ASB-ICW46C-0.5
NCBI Number | 12494 |
Application | FC, IHC, IP, ELISA, Control, Block |
Article No | ASB-ICW46C-0.5 |
Biosite Brand | Biosite |
Country Availability | all |
Clone | NIMR-5 |
Clone Type | monoclonal |
Concentration | 0.5 mg/mL |
Conjugation | Unconjugated |
Description | Rat Anti-Mouse CD38-UNLB |
Supplier | Nordic Biosite |
Format | Liquid |
Immunogen | BCL1 plasma membrane glycoproteins |
Isotype | IgG2a |
Notes | Murine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR) and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR). It is expressed at high levels on the surface of peripheral B-lineage cells and at low density on germinal center B cells from unimmunized mice. It has also been reported to be expressed at moderate levels on NK cells, a proportion of peripheral T cells, and a subpopulation of thymocytes which are mostly TCR gamma/delta+, CD4-, CD8-. Murine CD38 is also expressed by all Mac-1+ macrophages in the peritoneal cavities of unimmunized mice, but not by unstimulated bone-marrow-derived macrophages. Monoclonal antibodies to CD38 have been shown to induce B and T cell proliferation, protect B cells from apoptosis, and inhibit B lymphopoiesis. |
Alias Names | T10, ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase |
Previous Article No | ASB-E46421-0.5, ASB-163501, ASB-ICW46C-0.5 |
Product Type | Antibodies Primary |
Shipping Information | Ambient Temperature |
Size | 0.5 mg |
Source / Host | rat |
Species Reactivity | mouse |
Storage | 2-8°C |
Substrate / Buffer | Borate buffered saline, pH 8.2 |
Swiss-Prot No | P56528 |
Product Page Updated | 2024-02-02T14:39:29.088Z |
Volume | 1.0 mL |