Article No
ASB-RPAKPX-1
Mouse Anti-Human FADD-HRP
Mouse Anti-Human FADD-HRP
Antibodies Primary
Specifications
| NCBI Number | 8772 |
| Application | ELISA, WB |
| Article No | ASB-RPAKPX-1 |
| Biosite Brand | Biosite |
| Country Availability | all |
| Clone | 1A11 |
| Clone Type | monoclonal |
| Concentration | Lot specific |
| Conjugation | HRP |
| Description | Mouse Anti-Human FADD-HRP |
| Supplier | Nordic Biosite |
| Format | Liquid |
| Immunogen | Recombinant FADD |
| Isotype | IgG1 |
| Notes | Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter molecule involved in the Fas-mediated cell death pathway. FADD associates with the intracellular domain of FAS (CD95/APO-1) through their respective C-terminal death domains (DD). The N-terminal region of FADD contains a death effectors domain (DED) which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequent activation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated (ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosis which is inhibited by CrmA, a specific inhibitor of the interleukin-1beta-converting enzyme. FADD has also been shown under certain circumstances to promote cell survival and proliferation. |
| Alias Names | FAS-associated death domain protein, GIG3, MGC8528, MORT1 |
| Previous Article No | ASB-M8QGU8-1, ASB-C2CD3D |
| Product Type | Antibodies Primary |
| Shipping Information | Ambient Temperature |
| Size | 1 mL |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 2-8°C |
| Substrate / Buffer | 50% Glycerol/50% Phosphate buffered saline, pH 7.4 |
| Swiss-Prot No | Q13158 |
| Product Page Updated | 2024-01-11T10:51:07.446Z |
| Volume | 1.0 mL |
