Article No
ASB-BYWUBD-0.1
Mouse Anti-Human CD106-UNLB
Mouse Anti-Human CD106-UNLB
Antibodies Primary
Specifications
| NCBI Number | 7412, 396925 |
| Application | FC, IHC, ICC, IP, WB, ELISA, Block |
| Article No | ASB-BYWUBD-0.1 |
| Biosite Brand | Biosite |
| Country Availability | all |
| Clone | 1.G11B1 |
| Clone Type | monoclonal |
| Concentration | 0.1 mg/mL |
| Conjugation | Unconjugated |
| Description | Mouse Anti-Human CD106-UNLB |
| Supplier | Nordic Biosite |
| Format | Liquid |
| Isotype | IgG1 |
| Notes | CD106, also known as INCAM-110, is a 110 kDa vascular adhesion cell adhesion molecule-1 (VCAM-1) that is member of the immunoglobulin superfamily. CD106 is expressed predominantly on cytokine-activated vascular endothelium but has also been identified on interfollicular dendritic cells, some macrophages, and bone marrow stromal cells. Endothelial CD106 binds the integrins alpha4/beta1 (CD49d/CD29, VLA-4) and alpha4/beta7 and contributes to extravasation of lymphocytes, monocytes, basophils, and eosinophils (but not neutrophils) from blood vessels, particularly at sites of inflammation. Unlike the beta2 integrins, the CD106-VLA-4 interaction can mediate both the initial tethering and rolling of lymphocytes on endothelium as well as their subsequent arrest and firm adhesion. CD106 expressed on non-vascular tissues has been implicated in the interaction of hematopoietic progenitors with bone marrow stromal cells, B cell binding to follicular dendritic cells, costimulation of T cells, and embryonic development. The monoclonal antibody 1.G11B1 inhibits in vitro binding of lymphocytes and monocytes to VCAM-1 on stimulated endothelium. |
| Alias Names | VCAM-1, INCAM-110, vascular cell adhesion molecule-1 |
| Previous Article No | ASB-951001, ASB-BYWUBD-0.1 |
| Product Type | Antibodies Primary |
| Shipping Information | Ambient Temperature |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 2-8°C |
| Substrate / Buffer | Borate buffered saline, pH 8.2 |
| Swiss-Prot No | P19320 |
| Product Page Updated | 2024-01-11T10:51:07.446Z |
| Volume | 1.0 mL |
