Article No
ASB-8I8GH0-0.5
NCBI Number | 14972, 14964 |
Application | FC, ICC |
Article No | ASB-8I8GH0-0.5 |
Biosite Brand | Biosite |
Country Availability | all |
Clone | 34-1-2S |
Clone Type | monoclonal |
Concentration | 0.5 mg/mL |
Conjugation | FITC |
Description | Mouse Anti-Mouse H-2Kd/H-2Dd-FITC |
Supplier | Nordic Biosite |
Format | Liquid |
Immunogen | BDF1 mouse splenocytes |
Isotype | IgG2a |
Notes | The "classical" MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic alpha chains noncovalently associated with the invariant beta2-microglobulin. These antigens are expressed on most nucleated cells but expression varies on different cell types. MHC Class I molecules present endogenously synthesized peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. MHC Class I antigens expressed on thymic epithelial cells regulate the positive and negative selection of CD8+ T cells during T cell ontogeny. The monoclonal antibody 34-1-2S binds to a common determinant in the alpha3 domains of H-2Kd and H-2Dd in the presence or absence of beta2 microglobulin. It cross reacts with the alpha3 domain of H-2Kb. |
Alias Names | MHC Class I |
Previous Article No | ASB-191102, ASB-8I8GH0-0.5 |
Product Type | Antibodies Primary |
Shipping Information | Ambient Temperature |
Size | 0.5 mg |
Source / Host | mouse |
Species Reactivity | mouse |
Storage | 2-8°C |
Substrate / Buffer | Phosphate buffered saline containing < 0.1% sodium azide |
Swiss-Prot No | P01902, P01900 |
Product Page Updated | 2024-01-11T10:51:07.446Z |
Volume | 1.0 mL |