Article No
ASB-VHA73V-0.1
Rat Anti-Mouse CD40-APC
Rat Anti-Mouse CD40-APC
Antibodies Primary
Specifications
| NCBI Number | 21939 |
| Application | FC |
| Article No | ASB-VHA73V-0.1 |
| Biosite Brand | Biosite |
| Country Availability | all |
| Clone | 1C10 |
| Clone Type | monoclonal |
| Concentration | 0.1 mg/mL |
| Conjugation | APC |
| Description | Rat Anti-Mouse CD40-APC |
| Supplier | Nordic Biosite |
| Format | Liquid |
| Immunogen | sCD40 |
| Isotype | IgG2a |
| Notes | CD40 is a type I cell surface protein belonging to the tumor necrosis factor superfamily of cell surface receptors. In mice it is expressed on B lineage cells, follicular dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zone of secondary lymphoid organs. CD40 first becomes detectable on a subset of small pre-B II cells in bone marrow with the levels of CD40 expression increasing thereafter during B cell maturation. Immature B cells (IgM+IgDloB220lo) express intermediate levels of CD40, whereas mature B cells (IgM+IgDhiB220hi) express high levels. CD40 has a central role in B cell growth and differentiation, and signaling through CD40 in combination with IL-4 reportedly induces immunoglobulin isotype switching and secretion of IgE. The agonistic 1C10 antibody closely resembles gp39/CD40 ligand in its ability to stimulate proliferation of small, resting B lymphocytes in the absence of other cofactors. |
| Alias Names | TNFRSF5, Bp50 |
| Previous Article No | ASB-Y46K21-0.1, ASB-164511, ASB-VHA73V-0.1 |
| Product Type | Antibodies Primary |
| Shipping Information | Ambient Temperature |
| Size | 0.1 mg |
| Source / Host | rat |
| Species Reactivity | mouse |
| Storage | 2-8°C |
| Substrate / Buffer | Phosphate buffered saline containing < 0.1% sodium azide and a stabilizer |
| Swiss-Prot No | P27512 |
| Product Page Updated | 2024-01-11T10:51:07.446Z |
| Volume | 1.0 mL |
