Article No
ASB-J2WX18-0.5
Rat Anti-Mouse CD8α-LE/AF
Rat Anti-Mouse CD8α-LE/AF
Antibodies Primary
Specifications
| NCBI Number | 12525 |
| Application | FC, IHC, ICC, IP, Depletion, Block |
| Article No | ASB-J2WX18-0.5 |
| Biosite Brand | Biosite |
| Country Availability | all |
| Clone | 53-6.7 |
| Clone Type | monoclonal |
| Concentration | 0.5 mg/mL |
| Conjugation | LEAF |
| Description | Rat Anti-Mouse CD8α-LE/AF |
| Supplier | Nordic Biosite |
| Format | Liquid |
| Immunogen | Spleen cells or thymocyte membranes |
| Isotype | IgG2a |
| Notes | In the mouse, CD8 exists in two forms - (i) a CD8 heterodimer composed of an alpha chain (CD8 alpha) and a beta chain (CD8 beta); and (ii) a homodimer of two alpha chains. The heterodimer is found on the surface of essentially all thymocytes and the "suppressor/cytotoxic" subpopulation of mature T lymphocytes. Subsets of intestinal intraepithelial lymphocytes express CD8 alpha without CD8 beta. It has been suggested that CD8+ beta- T cells mature extrathymically, while development of the CD8 alpha+ beta+ population of T cells is thymus-dependent. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC class I-restricted CD8+ T cells. In vivo and in vitro treatment with the 53-6.7 monoclonal antibody effectively depletes CD8 alpha+ cells. The 53-6.7 monoclonal antibody also blocks allogeneic help specific for class I MHC antigens and T cell responses to IL-2. |
| Alias Names | Ly-2, Lyt-2, Ly-35, Ly-B, T8 |
| Previous Article No | ASB-Q0U8Y5-0.5, ASB-155014, ASB-J2WX18-0.5 |
| Product Type | Antibodies Primary |
| Shipping Information | Dry Ice |
| Size | 0.5 mg |
| Source / Host | rat |
| Species Reactivity | mouse |
| Storage | -20°C |
| Substrate / Buffer | Phosphate buffered saline, pH 7.4 |
| Swiss-Prot No | P01731 |
| Product Page Updated | 2024-01-11T10:51:07.446Z |
| Volume | 1.0 mL |
