Antibodies Primary


SPAK Antibody (Center)

Article No




Species Reactivity



80 µl



Source / Host


Product insert

Suggested protocols


MW 59474
NCBI Number NP_037365.2
Application WB
Article No AP7968c-ev
Country Availability DK, EE, FI, FO, GL, IS, LT, LV, NO, SE
Clone RB03418
Clone Type polyclonal
Description SPAK Antibody (Center)
Recommended Dilution 1:1000
Supplier Abgent
Isotype Ig
Keywords Crown Antibodies;Primary Antibodies;Metabolism;Signal Transduction
Notes SPAK is a serine/threonine kinase containing an N-terminal series of proline and alanine repeats (PAPA box), followed by a serine/threonine kinase catalytic domain, a nuclear localization signal, a consensus caspase cleavage recognition motif, and a C-terminal region. Northern blot analysis detects ubiquitous expression, most abundantly in brain and pancreas. SPAK can phosphorylate itself and an exogenous substrate in vitro. SPAK immunoprecipitates from transfected mammalian cells in a complex with another serine/threonine kinase that phosphorylates catalytically inactive SPAK. SPAK activates the p38 MAP kinase pathway in cotransfection assays. Full-length SPAK is expressed in the cytoplasm in transfected cells, while a mutant corresponding to caspase-cleaved STK39 localizes predominantly in the nucleus.
Alias Names STE20/SPS1-related proline-alanine-rich protein kinase, Ste-20-related kinase, DCHT, Serine/threonine-protein kinase 39, STK39, SPAK
Product Type Antibodies Primary
Research Area Metabolism
Size 80 µl
Source / Host rabbit
Species Reactivity human, mouse
Substrate / Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Technical Specifications This SPAK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 346-376 amino acids from the Central region of human SPAK.
Product Page Updated 2019-11-20T10:06:15.280Z

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