Article No
AP7112a-ev
MW | 46360 |
NCBI Number | NP_001116429.1;NP_005872.2 |
Accession Number | O14874 |
Application | WB |
Article No | AP7112a-ev |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
Clone | RB7751 |
Clone Type | polyclonal |
Conjugation | Unconjugated |
Description | BCKDK Antibody (Center) |
Recommended Dilution | 1:1000 |
Supplier | Abgent |
Entrez Gene ID | 10295 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Isotype | IgG |
Keywords | Primary Antibodies;Metabolism;Signal Transduction |
Notes | The second major step in the catabolism of the branched-chain amino acids, isoleucine, leucine, and valine, is irreversibly catalyzed by the branched-chain alpha-keto acid dehydrogenase complex (BCKD), an inner-mitochondrial enzyme complex composed of 3 catalytic components: a branched-chain alpha-keto acid decarboxylase (E1), a dihydrolipoyl transacylase (E2), and a dihydrolipoamide dehydrogenase (E3). The complex also contains 2 enzymes that regulated the state of activity of the BCKD complex: a kinase (BCKDK), and a phosphorylase. The ubiquitiously expressed kinase contains 1 histidine kinase domain. Maple syrup urine disease (MSUD) is a pathology secondary to an enzyme defect in the catabolic pathway of leucine, isoleucine, and valine. Accumulation of these amino acids and their corresponding keto acids results in encephalopathy and progressive neurodegeneration in infants not treated for MSUD. |
Alias Names | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, Branched-chain alpha-ketoacid dehydrogenase kinase, BCKD-kinase, BCKDHKIN, BCKDK |
Product Type | Antibodies Primary |
Research Area | Metabolism |
Size | 80 µl |
Source / Host | rabbit |
Species Reactivity | human |
Substrate / Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Technical Specifications | This BCKDK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-151 amino acids from the Central region of human BCKDK. |
Product Page Updated | 2023-11-23T14:38:54.086Z |