Article No
AP20776c
Specifications
| MW | 144605 |
| Accession Number | Q2M1K9 |
| Application | WB |
| Article No | AP20776c |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | RB49865 |
| Clone Type | polyclonal |
| Conjugation | Unconjugated |
| Description | ZNF423 Antibody (Center) |
| Recommended Dilution | 1:1000 |
| Supplier | Abgent |
| Entrez Gene ID | 23090 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Isotype | IgG |
| Keywords | Primary Antibodies;Neuroscience;Signal Transduction |
| Notes | Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. |
| Alias Names | Zinc finger protein 423, Olf1/EBF-associated zinc finger protein, hOAZ, Smad- and Olf-interacting zinc finger protein, ZNF423, KIAA0760, NPHP14, OAZ |
| Product Type | Antibodies Primary |
| Research area | Neuroscience |
| Size | 400 µl |
| Source / Host | rabbit |
| Species Reactivity | human |
| Substrate / Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Technical Specifications | This ZNF423 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 864-897 amino acids from the Central region of human ZNF423. |
| Product Page Updated | 2023-11-23T14:38:54.086Z |
