Antibodies Primary

ATXN7

NEW
ATXN7 Antibody (Center)

Article No

AP16926c

Application

WB

Species Reactivity

human

Size

400 µl

Clone

RB36286

Source / Host

rabbit

Product insert

Suggested protocols

Specifications

MW 95451
NCBI Number NP_000324.1;NP_001121621.2;NP_001170858.1
Application WB
Article No AP16926c
Country Availability DK, EE, FI, FO, GL, IS, LT, LV, NO, SE
Clone RB36286
Clone Type polyclonal
Description ATXN7 Antibody (Center)
Recommended Dilution 1:1000
Supplier Abgent
Isotype Ig
Keywords Primary Antibodies;Neuroscience
Notes The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the 'pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with spinocerebellar ataxia-7 contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele. The encoded protein is a component of the SPT3/TAF9/GCN5 acetyltransferase (STAGA) and TBP-free TAF-containing (TFTC) chromatin remodeling complexes, and it thus plays a role in transcriptional regulation. Alternative splicing results in multiple transcript variants.
Alias Names Ataxin-7, Spinocerebellar ataxia type 7 protein, ATXN7, SCA7
Product Type Antibodies Primary
Research Area Neuroscience
Size 400 µl
Source / Host rabbit
Species Reactivity human
Substrate / Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Technical Specifications This ATXN7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 354-381 amino acids from the Central region of human ATXN7.
Product Page Updated 2019-11-20T10:06:15.280Z

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