Article No
AP14167b-ev
MW | 73302 |
NCBI Number | NP_859066.1 |
Accession Number | Q53ET0 |
Application | WB |
Article No | AP14167b-ev |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
Clone | RB18081 |
Clone Type | polyclonal |
Conjugation | Unconjugated |
Description | CRTC2 Antibody (C-term) |
Recommended Dilution | 1:1000 |
Supplier | Abgent |
Entrez Gene ID | 200186 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Isotype | IgG |
Keywords | Primary Antibodies;Metabolism;Neuroscience;Signal Transduction |
Notes | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). |
Alias Names | CREB-regulated transcription coactivator 2, Transducer of regulated cAMP response element-binding protein 2, TORC-2, Transducer of CREB protein 2, CRTC2, TORC2 |
Product Type | Antibodies Primary |
Research Area | Metabolism |
Size | 80 µl |
Source / Host | rabbit |
Species Reactivity | human |
Substrate / Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Technical Specifications | This CRTC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 664-693 amino acids from the C-terminal region of human CRTC2. |
Product Page Updated | 2023-11-23T14:38:54.086Z |