Article No
ANC-300-030
anti-CD40 (human), mAb (EA-5) (Biotin)
anti-CD40 (human), mAb (EA-5) (Biotin)
Antibodies Primary
Specifications
| Application | ELISA, FA, FC |
| Article No | ANC-300-030 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | EA-5 |
| Clone Type | monoclonal |
| Conjugation | Biotin |
| Description | anti-CD40 (human), mAb (EA-5) (Biotin) |
| Supplier | Adipogen Life Sciences |
| Format | Liquid |
| Immunogen | Murine L cells transfectants expressing human CD40. |
| Isotype | IgG1 |
| Notes | CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.|Monoclonal Antibody. Isotype: Mouse IgG1. Clone: EA-5. Applications: ELISA, FACS, FUNC. 50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 5% Glycerol, 0.2% BSA, 0.04% NaN3 (as a preservative). CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary. |
| Alias Names | CD40L Receptor; CDw40; Tumor Necrosis Factor Receptor Superfamily Member 5; TNFRSF5 |
| Product Type | Antibodies Primary |
| Research area | Immunology |
| Shipping Information | BLUE ICE |
| Size | 100 µg |
| Source / Host | mouse |
| Species Reactivity | human, rat |
| Stability | Stable for at least 1 year after receipt when stored at +4°C. |
| Storage | 4°C |
| Substrate / Buffer | 50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 5% Glycerol, 0.2% BSA, 0.04% NaN3 (as a preservative). |
| Technical Specifications | Monoclonal Antibody. Isotype: Mouse IgG1. Clone: EA-5. Applications: ELISA, FACS, FUNC. 50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 5% Glycerol, 0.2% BSA, 0.04% NaN3 (as a preservative). CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary. |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
