CD45

Article No AMB-CEA754
Product Type Antibodies Primary
Application ELISA, WB, ICC, FC, IHC
Size 0.1mg

Specifications

MW 147.3kDa
Country Availability all
BioSite Brand BioSite mAb
Clone 1B9B10
Clone Type monoclonal
Description CD45
Supplier BioSite Mab
Entrez Gene ID 5788
Immunogen Purified recombinant fragment of human CD45 (AA: extra 431-577) expressed in E. Coli.
Isotype IgG2b
Notes The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
Alias Names PTPRC; LCA; LY5; B220; L-CA; T200; CD45R; GP180
Protocol ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: N/A; FCM: 1/200 - 1/400; IHC: N/A
Species Reactivity human
Storage 4 C, -20 C for long term storage
Substrate / Buffer Purified antibody in PBS with 0.05% sodium azide
Technical Specifications ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: N/A; FCM: 1/200 - 1/400; IHC: 1/200 - 1/1000
Product Page Updated 2018-10-15T09:15:17.802Z

Shipping info

The delivery time for this item is approximately 5-8 business days. If other deviations occur, this will be noted on the order confirmation or communicated via email. Please note, we do reserve the right to select the best packaging and shipping method in order to insure the stability of the product and allow efficient order tracking.

Species reactivity:

human human

Suggested protocols:

Western Blot

Western Blot

IHC-P

IHC-P