AKT1
Specifications
| MW | 55.7kDa |
| Country Availability | all |
| BioSite Brand | BioSite mAb |
| Clone | 1F7G2; |
| Clone Type | monoclonal |
| Description | Mouse Monoclonal Antibody to AKT1 |
| Supplier | BioSite Mab |
| Entrez Gene ID | 207 |
| Immunogen | Purified recombinant fragment of human AKT1 (AA: 1-150) expressed in E. Coli. |
| Isotype | IgG1 |
| Notes | The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. ; |
| Alias Names | AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA |
| Protocol | ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: ; FCM: 1/200 - 1/400 |
| Source / Host | mouse |
| Species Reactivity | human, monkey, rat |
| Storage | 4 C, -20 C for long term storage |
| Substrate / Buffer | Purified antibody in PBS with 0.05% sodium azide |
| Technical Specifications | ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: ; FCM: 1/200 - 1/400 |
| Product Page Updated | 2018-10-15T09:15:17.802Z |
Shipping info
The delivery time for this item is approximately 5-8 business days. If other deviations occur, this will be noted on the order confirmation or communicated via email. Please note, we do reserve the right to select the best packaging and shipping method in order to insure the stability of the product and allow efficient order tracking.
