Antibodies Primary

AKT1

NEW
Mouse Monoclonal Antibody to AKT1

Article No

AMB-9339

Application

ELISA, WB, IHC, ICC, FC

Species Reactivity

human
monkey
rat

Size

0.1mg

Clone

1F7G2;

Source / Host

mouse

Suggested protocols

Specifications

MW 55.7kDa
Application ELISA, WB, IHC, ICC, FC
Article No AMB-9339
BioSite Brand BioSite mAb
Clone 1F7G2;
Clone Type monoclonal
Description Mouse Monoclonal Antibody to AKT1
Supplier BioSite Mab
Entrez Gene ID 207
Immunogen Purified recombinant fragment of human AKT1 (AA: 1-150) expressed in E. Coli.
Isotype IgG1
Notes The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. ;
Alias Names AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA
Product Type Antibodies Primary
Protocol ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: ; FCM: 1/200 - 1/400
Size 0.1mg
Source / Host mouse
Species Reactivity human, monkey, rat
Storage 4°C -20°C for long term storage
Substrate / Buffer Purified antibody in PBS with 0.05% sodium azide
Technical Specifications ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: ; FCM: 1/200 - 1/400
Product Page Updated 2019-08-02T12:49:54.081Z

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