DNMT3L

Article No AMB-9330
Product Type Antibodies Primary
Application ELISA, WB, ICC
Size 0.1mg

Specifications

MW 43.6kDa
Country Availability all
BioSite Brand BioSite mAb
Clone 5H4A5;
Clone Type monoclonal
Description Mouse Monoclonal Antibody to DNMT3L
Supplier BioSite Mab
Entrez Gene ID 29947
Immunogen Purified recombinant fragment of human DNMT3L (AA: 147-386) expressed in E. Coli.
Isotype IgG1
Notes CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.;
Protocol ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: ; ICC: ; FCM:
Source / Host mouse
Species Reactivity human
Storage 4 C, -20 C for long term storage
Substrate / Buffer Purified antibody in PBS with 0.05% sodium azide
Technical Specifications ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: ; ICC: ; FCM:
Product Page Updated 2018-10-15T09:15:17.802Z

Shipping info

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Source/Host:

mouse mouse

Species reactivity:

human human

Suggested protocols:

Western Blot

Western Blot