CASP3

Article No AMB-9108
Product Type Antibodies Primary
Application ELISA, WB, ICC, FC
Size 0.1mg

Specifications

MW 31.6kDa
Country Availability all
BioSite Brand BioSite mAb
Clone 3D4D7;
Clone Type monoclonal
Description Mouse Monoclonal Antibody to CASP3
Supplier BioSite Mab
Entrez Gene ID 836
Immunogen Purified recombinant fragment of human CASP3 (AA: 29-175) expressed in E. Coli.
Isotype IgG1
Notes This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Alias Names CPP32; SCA-1; CPP32B
Protocol ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: ; ICC: ; FCM: 1/200 - 1/400
Source / Host mouse
Species Reactivity human
Storage 4 C, -20 C for long term storage
Substrate / Buffer Purified antibody in PBS with 0.05% sodium azide
Technical Specifications ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: ; ICC: ; FCM: 1/200 - 1/400
Product Page Updated 2018-10-15T09:15:17.802Z

Shipping info

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Source/Host:

mouse mouse

Species reactivity:

human human

Suggested protocols:

Western Blot

Western Blot