WAS

Article No AMB-9072
Product Type Antibodies Primary
Application ELISA, WB, IHC, FC
Size 0.1mg

Specifications

MW 53kDa
Country Availability all
BioSite Brand BioSite mAb
Clone 7B10E4;
Clone Type monoclonal
Description Mouse Monoclonal Antibody to WAS
Supplier BioSite Mab
Entrez Gene ID 7454
Immunogen Purified recombinant fragment of human WAS (AA: 57-170) expressed in E. Coli.
Isotype IgG2a
Notes The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.
Alias Names THC; IMD2; SCNX; THC1; WASP
Protocol ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Source / Host mouse
Species Reactivity human
Storage 4 C, -20 C for long term storage
Substrate / Buffer Purified antibody in PBS with 0.05% sodium azide.
Technical Specifications ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Product Page Updated 2018-10-15T09:15:17.802Z

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Source/Host:

mouse mouse

Species reactivity:

human human

Suggested protocols:

Western Blot

Western Blot

IHC-P

IHC-P