CD22

Article No AMB-8929
Product Type Antibodies Primary
Application ELISA, WB, ICC, FC
Size 0.1mg

Specifications

MW 95.3kDa
Country Availability all
BioSite Brand BioSite mAb
Clone 1A3A11;
Clone Type monoclonal
Description Mouse Monoclonal Antibody to CD22
Supplier BioSite Mab
Entrez Gene ID 933
Immunogen Purified recombinant fragment of human CD22 (AA: 621-725) expressed in E. Coli.
Isotype IgG1
Notes CD22 may be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules ;
Alias Names SIGLEC2; SIGLEC-2
Protocol ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Source / Host mouse
Species Reactivity human
Storage 4 C, -20 C for long term storage
Substrate / Buffer Purified antibody in PBS with 0.05% sodium azide
Technical Specifications ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Product Page Updated 2018-10-15T09:15:17.802Z

Shipping info

The delivery time for this item is approximately 5-8 business days. If other deviations occur, this will be noted on the order confirmation or communicated via email. Please note, we do reserve the right to select the best packaging and shipping method in order to insure the stability of the product and allow efficient order tracking.

Source/Host:

mouse mouse

Species reactivity:

human human

Suggested protocols:

Western Blot

Western Blot