FAS

Article No AMB-8764
Product Type Antibodies Primary
Application ELISA, WB, FC
Size 0.1mg

Specifications

MW 37.7kDa
Country Availability all
BioSite Brand BioSite mAb
Clone 4F8D6;
Clone Type monoclonal
Description Mouse Monoclonal Antibody to FAS
Supplier BioSite Mab
Entrez Gene ID 355
Immunogen Purified recombinant fragment of human FAS expressed in E. Coli. ;
Isotype IgG1
Notes The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
Alias Names APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6
Protocol ELISA: 1/10000; WB: 1/500 - 1/2000; FCM: 1/200 - 1/400
Source / Host mouse
Species Reactivity human
Storage 4 C, -20 C for long term storage
Substrate / Buffer Purified antibody in PBS with 0.05% sodium azide
Technical Specifications ELISA: 1/10000; WB: 1/500 - 1/2000; FCM: 1/200 - 1/400
Product Page Updated 2018-10-15T09:15:17.802Z

Shipping info

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Source/Host:

mouse mouse

Species reactivity:

human human

Suggested protocols:

Western Blot

Western Blot