CASP8

Article No AMB-8715
Product Type Antibodies Primary
Application ELISA, WB, IHC, FC
Size 100μl

Specifications

MW 26kDa
Country Availability all
BioSite Brand BioSite mAb
Clone 1H11;
Clone Type monoclonal
Description Mouse Monoclonal Antibody to CASP8
Supplier BioSite Mab
Entrez Gene ID 841
Immunogen Purified recombinant fragment of human CASP8 expressed in E. Coli. ;
Isotype IgG1
Notes This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.
Alias Names CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; FLJ17672; MGC78473
Protocol ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Source / Host mouse
Species Reactivity human, mouse, monkey, rat
Storage 4 C, -20 C for long term storage
Substrate / Buffer Ascitic fluid containing 0.03% sodium azide.
Technical Specifications ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Product Page Updated 2018-10-15T09:15:17.802Z

Shipping info

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Source/Host:

mouse mouse

Species reactivity:

human, mouse, monkey, rat human mouse monkey rat

Suggested protocols:

Western Blot

Western Blot

IHC-P

IHC-P