Article No
AMB-ZDYHGF-100
MW | 68kDa |
Application | WB, ELISA, FC, ICC |
Article No | AMB-ZDYHGF-100 |
Biosite Brand | Biosite mAb |
Country Availability | all |
Clone | 5G9 |
Clone Type | monoclonal |
Conjugation | Unconjugated |
Description | BLNK Primary Antibody |
Supplier | Nordic Biosite |
Entrez Gene ID | 29760 |
Format | Ascitic fluid containing 0.03% sodium azide. |
Immunogen | Purified recombinant fragment of human BLNK expressed in E. Coli. |
Isotype | IgG1 |
Notes | This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Alias Names | AGM4; BASH; LY57; SLP65; BLNK-S; SLP-65; MGC111051 |
Previous Article No | AMB-8668 |
Product Type | Antibodies Primary |
Protocol | ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400 |
Size | 100µl |
Source / Host | mouse |
Species Reactivity | human, mouse |
Storage | 4°C -20°C for long term storage |
Substrate / Buffer | Ascitic fluid containing 0.03% sodium azide. |
Technical Specifications | ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400 |
Product Page Updated | 2024-01-25T14:27:22.065Z |