Antibodies Primary

CDH1

NEW
Mouse Monoclonal Antibody to CDH1

Article No

AMB-8565

Application

ELISA, WB

Species Reactivity

human
mouse
monkey

Size

100μl

Clone

7A2;

Source / Host

mouse

Suggested protocols

Specifications

MW 135kDa
Application ELISA, WB
Article No AMB-8565
BioSite Brand BioSite mAb
Clone 7A2;
Clone Type monoclonal
Description Mouse Monoclonal Antibody to CDH1
Supplier BioSite Mab
Entrez Gene ID 999
Immunogen Purified recombinant fragment of human CDH1 expressed in E. Coli.
Isotype IgG1
Notes E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.
Alias Names UVO; CDHE; ECAD; LCAM; Arc-1; CD324; CDH1
Product Type Antibodies Primary
Protocol ELISA: 1/10000; WB: 1/500 - 1/2000
Size 100μl
Source / Host mouse
Species Reactivity human, mouse, monkey
Storage 4°C -20°C for long term storage
Substrate / Buffer Ascitic fluid containing 0.03% sodium azide. ;
Technical Specifications ELISA: 1/10000; WB: 1/500 - 1/2000
Product Page Updated 2019-08-02T12:49:54.081Z

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