CDH1

Article No AMB-8565
Product Type Antibodies Primary
Application ELISA, WB
Size 100μl

Specifications

MW 135kDa
Country Availability all
BioSite Brand BioSite mAb
Clone 7A2;
Clone Type monoclonal
Description Mouse Monoclonal Antibody to CDH1
Supplier BioSite Mab
Entrez Gene ID 999
Immunogen Purified recombinant fragment of human CDH1 expressed in E. Coli.
Isotype IgG1
Notes E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.
Alias Names UVO; CDHE; ECAD; LCAM; Arc-1; CD324; CDH1
Protocol ELISA: 1/10000; WB: 1/500 - 1/2000
Source / Host mouse
Species Reactivity human, mouse, monkey
Storage 4 C, -20 C for long term storage
Substrate / Buffer Ascitic fluid containing 0.03% sodium azide. ;
Technical Specifications ELISA: 1/10000; WB: 1/500 - 1/2000
Product Page Updated 2018-10-15T09:15:17.802Z

Shipping info

The delivery time for this item is approximately 5-8 business days. If other deviations occur, this will be noted on the order confirmation or communicated via email. Please note, we do reserve the right to select the best packaging and shipping method in order to insure the stability of the product and allow efficient order tracking.

Source/Host:

mouse mouse

Species reactivity:

human, mouse, monkey human mouse monkey

Suggested protocols:

Western Blot

Western Blot