ATP2C1

Article No AMB-8440
Product Type Antibodies Primary
Application ELISA, WB, IHC
Size 100μl

Specifications

MW 100kDa
Country Availability all
BioSite Brand BioSite mAb
Clone 4G12;
Clone Type monoclonal
Description Mouse Monoclonal Antibody to ATP2C1
Supplier BioSite Mab
Entrez Gene ID 27032
Immunogen Purified recombinant fragment of ATP2C1 expressed in E. Coli.
Isotype IgG1
Notes ATP2C1, also known as PMR1, it belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The human homologue, ATP2C1 (also designated SPLA in rat), also regulates the transport of calcium in the Golgi complex and is related to other P-type ATPases family members, such as the sarco(endo)plasmic calcium ATPase (SERCA) and the plasma membrane calcium ATPase (PCMA). ATP2C1 is a transmembrane protein that exists as two splice variants, which vary by 20 amino acids. Defects in ATP2C1 cause Hailey-Hailey disease, which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.
Alias Names HHD; BCPM; PMR1; SPCA1
Protocol ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000
Source / Host mouse
Species Reactivity human, monkey
Storage 4 C, -20 C for long term storage
Substrate / Buffer Ascitic fluid containing 0.03% sodium azide.
Technical Specifications ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000
Product Page Updated 2018-10-15T09:15:17.802Z

Shipping info

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Source/Host:

mouse mouse

Species reactivity:

human, monkey human monkey

Suggested protocols:

Western Blot

Western Blot

IHC-P

IHC-P