Article No
AMB-7HGAJ8-100
ATP2C1 Primary Antibody
ATP2C1 Primary Antibody
Antibodies Primary
Specifications
| MW | 100kDa |
| Application | WB, ELISA |
| Article No | AMB-7HGAJ8-100 |
| Biosite Brand | Biosite mAb |
| Country Availability | all |
| Clone | 4G12 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | ATP2C1 Primary Antibody |
| Supplier | Nordic Biosite |
| Entrez Gene ID | 27032 |
| Format | Ascitic fluid containing 0.03% sodium azide. |
| Immunogen | Purified recombinant fragment of ATP2C1 expressed in E. Coli. |
| Isotype | IgG1 |
| Notes | ATP2C1, also known as PMR1, it belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The human homologue, ATP2C1 (also designated SPLA in rat), also regulates the transport of calcium in the Golgi complex and is related to other P-type ATPases family members, such as the sarco(endo)plasmic calcium ATPase (SERCA) and the plasma membrane calcium ATPase (PCMA). ATP2C1 is a transmembrane protein that exists as two splice variants, which vary by 20 amino acids. Defects in ATP2C1 cause Hailey-Hailey disease, which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling. |
| Alias Names | HHD; BCPM; PMR1; SPCA1 |
| Previous Article No | AMB-8440 |
| Product Type | Antibodies Primary |
| Protocol | ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000 |
| Size | 100µl |
| Source / Host | mouse |
| Species Reactivity | human, monkey |
| Storage | 4°C -20°C for long term storage |
| Substrate / Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Technical Specifications | ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000 |
| Product Page Updated | 2024-01-25T14:27:22.065Z |
