ERBB3

Article No AMB-8391
Product Type Antibodies Primary
Application ELISA, WB, ICC
Size 100μl

Specifications

MW 148kDa
Country Availability all
BioSite Brand BioSite mAb
Clone 2F9;
Clone Type monoclonal
Description Mouse Monoclonal Antibody to ERBB3
Supplier BioSite Mab
Entrez Gene ID 2065
Immunogen Purified recombinant extracellular fragment of human ERBB3 (aa22-369) fused with hIgGFc tag expressed in HEK293 cells.
Isotype IgG1
Notes ERBB3, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian). It is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
Alias Names HER3; c-erbB3
Protocol ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: 1/200 - 1/1000
Source / Host mouse
Species Reactivity human
Storage 4 C, -20 C for long term storage
Substrate / Buffer Ascitic fluid containing 0.03% sodium azide.
Technical Specifications ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: 1/200 - 1/1000
Product Page Updated 2018-10-15T09:15:17.802Z

Shipping info

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Source/Host:

mouse mouse

Species reactivity:

human human

Suggested protocols:

Western Blot

Western Blot