Article No
AMB-JJKK5N-100
DDR1 Primary Antibody
DDR1 Primary Antibody
Antibodies Primary
Specifications
| Application | WB, ELISA |
| Article No | AMB-JJKK5N-100 |
| Biosite Brand | Biosite mAb |
| Country Availability | all |
| Clone | 2G4E12 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | DDR1 Primary Antibody |
| Supplier | Nordic Biosite |
| Entrez Gene ID | 780 |
| Format | Ascitic fluid containing 0.03% sodium azide. |
| Immunogen | Purified recombinant fragment of DDR1 (aa602-681) expressed in E. Coli. |
| Isotype | IgG1 |
| Notes | DDR1: discoidin domain receptor tyrosine kinase 1. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants. |
| Alias Names | CAK; DDR; NEP; PTK3; RTK6; TRKE; CD167 |
| Previous Article No | AMB-8284 |
| Product Type | Antibodies Primary |
| Protocol | ELISA: 1/10000; WB: 1/500 - 1/2000 |
| Size | 100µl |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 4°C -20°C for long term storage |
| Substrate / Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Technical Specifications | ELISA: 1/10000; WB: 1/500 - 1/2000 |
| Product Page Updated | 2024-01-25T14:27:22.065Z |
