Article No
AMB-L4ZLKT-100
MW | 56kDa |
Application | WB, ELISA |
Article No | AMB-L4ZLKT-100 |
Biosite Brand | Biosite mAb |
Country Availability | all |
Clone | 2G1D5 |
Clone Type | monoclonal |
Conjugation | Unconjugated |
Description | CHK1 Primary Antibody |
Supplier | Nordic Biosite |
Entrez Gene ID | 1111 |
Format | Ascitic fluid containing 0.03% sodium azide. |
Immunogen | Purified recombinant fragment of CHK1 expressed in E. Coli. |
Isotype | IgG1 |
Notes | CHK1, also known as CHEK1, it is a kinase that phosphorylates cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. Cdc25, when phosphorylated on serine 216 by chk1 becomes bound by an adaptor protein in the cytoplasm. Therefore it is inhibited from removing the inhibiting phosphate from MPF (mitotic/maturation promoting factor) added by Wee1. Consequently, a cell is prevented from entering mitosis. Chk1 can also phosphorylate p53 at Ser20 in vitro. |
Alias Names | CHEK1 |
Previous Article No | AMB-8116 |
Product Type | Antibodies Primary |
Protocol | ELISA: 1/10000; WB: 1/500 - 1/2000 |
Size | 100µl |
Source / Host | mouse |
Species Reactivity | human, mouse |
Storage | 4°C -20°C for long term storage |
Substrate / Buffer | Purified antibody in PBS containing 0.03% sodium azide. |
Technical Specifications | ELISA: 1/10000; WB: 1/500 - 1/2000 |
Product Page Updated | 2024-01-25T14:27:22.065Z |