MSH2

Article No AMB-8111
Product Type Antibodies Primary
Application ELISA, WB, IHC, ICC
Size 100┬Ál

Specifications

MW 105kDa
Country Availability all
BioSite Brand BioSite mAb
Clone 1B3;
Clone Type monoclonal
Description Mouse Monoclonal Antibody to MSH2
Supplier BioSite Mab
Entrez Gene ID 4436
Immunogen Purified recombinant fragment of human MSH2 expressed in E. Coli.
Isotype IgG1
Notes MSH2 is a 100 kDa nuclear antigen and encodes a protein of 934 amino acids. The MSH2 gene is one of 4 known genes encoding proteins involved in the repair of mismatch nucleotides following DNA replication or repair. Mutations in the MSH2 gene contribute to the development of sporadic colorectal carcinoma. MSHS mutations are responsible for 50% of inherited non-polyposis colorectal (HNPCC). The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process.
Alias Names FCC1; COCA1; HNPCC; LCFS2
Protocol ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000
Source / Host mouse
Species Reactivity human, monkey
Storage 4 C, -20 C for long term storage
Substrate / Buffer Ascitic fluid containing 0.03% sodium azide.
Technical Specifications ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000
Product Page Updated 2018-10-15T09:15:17.802Z

Shipping info

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Source/Host:

mouse mouse

Species reactivity:

human, monkey human monkey

Suggested protocols:

Western Blot

Western Blot

IHC-P

IHC-P