C17ORF53

C17ORF53

Article No AMB-8050
Product Type Antibodies Primary
Application ELISA, WB
Size 0.1mg

Specifications

MW 69.8kDa
Country Availability all
BioSite Brand BioSite mAb
Clone 3E10H2;
Clone Type monoclonal
Description Mouse Monoclonal Antibody to C17ORF53
Supplier BioSite Mab
Entrez Gene ID 78995
Immunogen Purified recombinant fragment of human C17ORF53 (AA: 282-527) expressed in E. Coli.
Isotype IgG1
Notes C17orf53 (chromosome 17 open reading frame 53) is a 647 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17. ; ;
Protocol ELISA: 1/10000; WB: 1/500 - 1/2000
Source / Host mouse
Species Reactivity human
Storage 4 C, -20 C for long term storage
Substrate / Buffer Purified antibody in PBS with 0.05% sodium azide
Technical Specifications ELISA: 1/10000; WB: 1/500 - 1/2000
Product Page Updated 2018-10-15T09:15:17.802Z

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Shipping info

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Source/Host:

mouse mouse

Species reactivity:

human human

Suggested protocols:

Western Blot

Western Blot