Antibodies Primary

HCK

NEW
HCK Antibody

Article No

AM8476b

Application

IF, WB

Species Reactivity

human

Size

200 µl

Clone

1508CT602.13.1

Source / Host

mouse

Product insert

Specifications

MW 59600
Application IF, WB
Article No AM8476b
Country Availability SE, FI, DK, NO, IS, EE, LV, LT, FO, GL
Clone 1508CT602.13.1
Clone Type monoclonal
Description HCK Antibody
Recommended Dilution 1:25
Supplier Abgent
Isotype IgG1 k
Keywords Crown Antibodies;Primary Antibodies;Immunology;Signal Transduction
Notes Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.
Alias Names Tyrosine-protein kinase HCK, Hematopoietic cell kinase, Hemopoietic cell kinase, p59-HCK/p60-HCK, p59Hck, p61Hck, HCK
Product Type Antibodies Primary
Research Area Immunology
Size 200 µl
Source / Host mouse
Species Reactivity human
Substrate / Buffer Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Technical Specifications This HCK antibody is generated from a mouse immunized with a recombinant protein of human HCK.
Product Page Updated 2020-06-09T12:26:26.349Z

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