Article No
AM2201b-ev
Specifications
| MW | 32575 |
| NCBI Number | NP_001032827.1;NP_002511.1;NP_954654.1 |
| Accession Number | P06748 |
| Application | WB |
| Article No | AM2201b-ev |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | 1042CT5.2.1 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | NPM1 Antibody |
| Recommended Dilution | 1:1000 |
| Supplier | Abgent |
| Entrez Gene ID | 4869 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Isotype | IgG1 |
| Keywords | Crown Antibodies;Primary Antibodies |
| Notes | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. |
| Alias Names | Nucleophosmin, NPM, Nucleolar phosphoprotein B23, Nucleolar protein NO38, Numatrin, NPM1, NPM |
| Product Type | Antibodies Primary |
| Size | 80 µl |
| Source / Host | mouse |
| Species Reactivity | human |
| Substrate / Buffer | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Technical Specifications | Purified His-tagged NPM1 protein was used to produced this monoclonal antibody. |
| Product Page Updated | 2023-11-23T14:38:54.086Z |
