(R)-CR8

Article No AG-MR-C0003-M010
Product Type Chemicals & Biochemicals
Research Area Cell Death
Format Powder
Size 10 mg

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Specifications

CAS No 294646-77-8
MW 431.5
Country Availability DK, EE, FI, IS, LT, LV, NO, SE
Data Sheet Link https://www.adipogen.com/productmanagement/resource/download/type/sheet/id/10538
Description (R)-CR8
Supplier Adipogen Life Sciences
Notes Potent and selective inhibitor of cyclin dependent kinases CDK1, CDK2, CDK5, CDK7 and CDK9. Apoptosis inducer. Inhibits the proliferation of various cancer cell lines. Casein kinase 1 (CK1delta/epsilon) and glycogen synthase kinase (GSK-3alpha/beta) inhibitor. Potential anti-inflammatory compound. Potential antidiabetic compound.
Molecular Formula C24H29N7O
Alias Names 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine
Purity >98% (NMR)
References CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases: K. Bettayeb, et al.; Oncogene 27, 5797 (2008) | Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1: N. Oumata, et al.; J. Med. Chem. 51, 5229 (2008) | CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells: K. Bettayeb, et al.; Genes Cancer 1, 369 (2010) | CR8, a selective and potent CDK inhibitor, provides neuroprotection in experimental traumatic brain injury. S.V. Kabadi, et al.; Neurotherapeutics 9, 405 (2012) | Inhibition of NF-kappaB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes prosurvival stimuli to induce apoptosis in chronic lymphocytic leukemia cells: E. Cosimo, et al.; Clin. Cancer Res. 19, 2393 (2013)
Solubility Soluble in DMSO or ethanol.
Stability Stable for at least 2 years after receipt when stored at -20°C.
Storage -20°C
Technical Specifications Chemical. CAS: 294646-77-8. Formula: C24H29N7O. MW: 431.5. Potent and selective inhibitor of cyclin dependent kinases CDK1, CDK2, CDK5, CDK7 and CDK9. Apoptosis inducer. Inhibits the proliferation of various cancer cell lines. Casein kinase 1 (CK1delta/epsilon) and glycogen synthase kinase (GSK-3alpha/beta) inhibitor. Potential anti-inflammatory compound. Potential antidiabetic compound.
Product Page Updated 2019-05-13T13:51:50.564Z

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