(S)-Roscovitine

Article No AG-MR-C0002-M005
Product Type Chemicals & Biochemicals
Research Area Cell Death
Format Powder
Size 5 mg

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Specifications

CAS No 186692-45-5
MW 354.5
Country Availability DK, EE, FI, IS, LT, LV, NO, SE
Data Sheet Link https://www.adipogen.com/productmanagement/resource/download/type/sheet/id/10541
Description (S)-Roscovitine
Supplier Adipogen Life Sciences
Notes (S)-enantiomer of (R)-roscovitine (Prod. No. MR-C0001). Potent selective cyclin-dependent kinase 1 (CDK1) inhibitor. Potential neuroprotectant for stroke. Crosses the blood brain barrier. Inhibits CDK5, consequently blocking hypoxia-induced apoptosis in neurons. Potential anti-inflammatory compound. Potential antidiabetic compound.
Molecular Formula C19H26N6O
Alias Names 6-Benzylamino-2-(S)-[(1-ethyl)-2-hydroxyethylamino]-9-isopropylpurine
Purity >99% (NMR)
References Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5: L. Meijer, et al.; Eur. J. Biochem. 243, 527 (1997) | Maintenance of meiotic arrest in bovine oocytes using the S-enantiomer of roscovitine: effects on maturation, fertilization and subsequent embryo development in vitro: P. Coy, et al.; Reprod. 129, 19 (2005) | Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models: B. Menn, et al.; PLoS One 5, e12117 (2010)
Solubility Soluble in DMSO, ethanol or methanol.
Stability Stable for at least 2 years after receipt when stored at -20°C.
Storage -20°C
Technical Specifications Chemical. CAS: 186692-45-5. Formula: C19H26N6O. MW: 354.5. (S)-enantiomer of (R)-roscovitine (Prod. No. MR-C0001). Potent selective cyclin-dependent kinase 1 (CDK1) inhibitor. Potential neuroprotectant for stroke. Crosses the blood brain barrier. Inhibits CDK5, consequently blocking hypoxia-induced apoptosis in neurons. Potential anti-inflammatory compound. Potential antidiabetic compound.
Product Page Updated 2019-05-13T13:51:50.564Z

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