Article No
AG-CR1-3909-M005
MBIMPH F-Analog 2
MBIMPH F-Analog 2
Chemicals & Biochemicals
Specifications
| CAS No | n.d. |
| MW | 299.3 |
| Article No | AG-CR1-3909-M005 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Description | MBIMPH F-Analog 2 |
| Supplier | Adipogen Life Sciences |
| Format | Powder |
| Notes | Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =5nM). Displays high selectivity over all other HDACs (IC50=0.2-11µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and biochemical potency against HDAC6 compared to tubastatin A (AG-CR1-3900). HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.|Chemical. Formula: C16H14FN3O2. MW: 299.3. Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =5nM). Displays high selectivity over all other HDACs (IC50=0.2-11µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and biochemical potency against HDAC6 compared to tubastatin A (AG-CR1-3900). HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration. |
| Molecular Formula | C16H14FN3O2 |
| Alias Names | MBIMPH Fluorinated Analog 2; 4-((6-Fluoro-2-methyl-1H-benzo[d]imidazol-1-yl)methyl)-N-hydroxybenzamide |
| Product Type | Chemicals & Biochemicals |
| Purity | >95% |
| Research area | Inflammation |
| Shipping Information | RT |
| Size | 5 mg |
| Solubility | Soluble in DMSO, ethanol or methanol. |
| Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Storage | -20°C, 4°C |
| Technical Specifications | Chemical. Formula: C16H14FN3O2. MW: 299.3. Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =5nM). Displays high selectivity over all other HDACs (IC50=0.2-11µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and biochemical potency against HDAC6 compared to tubastatin A (AG-CR1-3900). HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration. |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
