Article No
AG-CR1-3905-M001
Specifications
| CAS No | 1392835-64-1 |
| MW | 217.2 |
| Article No | AG-CR1-3905-M001 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Description | PMPH |
| Supplier | Adipogen Life Sciences |
| Format | Powder |
| Notes | Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =11nM). Displays high selectivity over HDAC1 (IC50=1.5µM). Neuroprotective. Effectively prevents neuronal cell death upon oxidative stress induction by HCA and selectively induces cellular alpha-tubulin hyperacetylation. HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.|Chemical. CAS: 1392835-64-1. Formula: C11H11N3O2. MW: 217.2. Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =11nM). Displays high selectivity over HDAC1 (IC50=1.5µM). Neuroprotective. Effectively prevents neuronal cell death upon oxidative stress induction by HCA and selectively induces cellular alpha-tubulin hyperacetylation. HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration. |
| Molecular Formula | C11H11N3O2 |
| Alias Names | 4-((1H-Pyrazol-1-yl)methyl)-N-hydroxybenzamide |
| Product Type | Chemicals & Biochemicals |
| Purity | >98% |
| Research area | Inflammation |
| Shipping Information | RT |
| Size | 1 mg |
| Solubility | Soluble in DMSO, methanol or ethanol. |
| Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Storage | -20°C, 4°C |
| Technical Specifications | Chemical. CAS: 1392835-64-1. Formula: C11H11N3O2. MW: 217.2. Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =11nM). Displays high selectivity over HDAC1 (IC50=1.5µM). Neuroprotective. Effectively prevents neuronal cell death upon oxidative stress induction by HCA and selectively induces cellular alpha-tubulin hyperacetylation. HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration. |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
