ACY-775

Article No AG-CR1-3903-M001
Product Type Chemicals & Biochemicals
Research Area Inflammation
Format Powder
Size 1 mg

This product is not available for sale in your country. Please feel free to contact the help desk if you have any questions.

Specifications

CAS No 1375466-18-4
MW 330.4
Country Availability DK, EE, FI, IS, LT, LV, NO, SE
Data Sheet Link https://www.adipogen.com/productmanagement/resource/download/type/sheet/id/10594
Description ACY-775
Supplier Adipogen Life Sciences
Notes Chemical. CAS: 1375466-18-4. Formula: C17H19FN4O2. MW: 330.4. Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =7.5nM). Displays high selectivity over HDAC1-9 (IC50=1-10µM). Shows improved brain bioavailability compared to tubastatin A (Prod. No. AG-CR1-3900). Induces hyperacetylation of alpha-tubulin in brain without concurrently altering the acetylation of histones. Shows antidepressant activity. HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.
Molecular Formula C17H19FN4O2
Alias Names 2-((1-(3-Fluorophenyl)cyclohexyl)amino)-N-hydroxypyrimidine-5-carboxamide
Purity >95% (HPLC)
References Histone deacetylase (HDAC) inhibitors as single agents induce multiple myeloma cell death principally through the inhibition of class I HDAC: S. Mithraprabhu, et al.; Br. J. Haematol. 162, 559 (2013) | Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer: J.S. Riley, et al.; Cell Death Dis. 4, e951 (2013) | RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth: K.A. Wilson-Edell, et al.; Oncotarget 5, 5165 (2014) | Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability: J. Jochems, et al.; Neuropsychopharmacol. 39, 389 (2014)
Solubility Soluble in DMSO, methanol or ethanol.
Source / Host synthetic
Storage -20°C
Technical Specifications Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =7.5nM). Displays high selectivity over HDAC1-9 (IC50=1-10µM). Shows improved brain bioavailability compared to tubastatin A (Prod. No. AG-CR1-3900). Induces hyperacetylation of alpha-tubulin in brain without concurrently altering the acetylation of histones. Shows antidepressant activity. HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.

Shipping info

The delivery time for this item is approximately 5-8 business days. If other deviations occur, this will be noted on the order confirmation or communicated via email. Please note, we do reserve the right to select the best packaging and shipping method in order to insure the stability of the product and allow efficient order tracking.

Source/Host:

synthetic

Product insert:

Product data sheet

Datasheet