Article No
AG-CR1-3688-M005
(+)-Etomoxir . Na
(+)-Etomoxir . Na
Chemicals & Biochemicals
Specifications
| CAS No | 828934-41-4 |
| MW | 297.8 . 23.0 |
| Article No | AG-CR1-3688-M005 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Description | (+)-Etomoxir . Na |
| Supplier | Adipogen Life Sciences |
| Format | Powder |
| Notes | Chemical. CAS: 828934-41-4. Formula: C15H18ClO4 . Na. MW: 297.8 . 23.0. . Irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1a) a mitochondrial enzyme involved in fatty acid beta-oxidation. CPR-1a on the outer face of the inner mitochondrial membrane, consequently prevents the formation of acyl carnitines, a step that is necessary for the transport of fatty acyl chains from the cytosol into the intermembrane space of the mitochondria, essential for the production of ATP from fatty acid oxidation. Fatty acid beta-oxidation (FAO) inhibitor. By regulating fatty acid oxidation it has hypoketonaemic, hypocholesteraemic and hypolipogenic effect, and the potential to affect ketogenesis, cholesterol synthesis and gluconeogenesis. Useful agent for immunometabolism research. Anticancer, antiobesity and antidiabetes agent. Increases food intake and reduces hepatic ATP/ADP ratio. Mitochondrial fatty acid oxidation may provide NADPH for defense against oxidative stress and prevent ATP loss and cell death. PPARalpha activator/agonist. Shows non-specific effects on oxidative metabolism and cellular redox and induces acute production of ROS with associated evidence of severe oxidative stress in proliferating T cells at above 5µM concentration. Shown to have potentiating effects on chemotherapeutics agents.|Irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1a) a mitochondrial enzyme involved in fatty acid beta-oxidation. CPR-1a on the outer face of the inner mitochondrial membrane, consequently prevents the formation of acyl carnitines, a step that is necessary for the transport of fatty acyl chains from the cytosol into the intermembrane space of the mitochondria, essential for the production of ATP from fatty acid oxidation. Fatty acid beta-oxidation (FAO) inhibitor. By regulating fatty acid oxidation it has hypoketonaemic, hypocholesteraemic and hypolipogenic effect, and the potential to affect ketogenesis, cholesterol synthesis and gluconeogenesis. Useful agent for immunometabolism research. Anticancer, antiobesity and antidiabetes agent. Increases food intake and reduces hepatic ATP/ADP ratio. Mitochondrial fatty acid oxidation may provide NADPH for defense against oxidative stress and prevent ATP loss and cell death. PPARalpha activator/agonist. Shows non-specific effects on oxidative metabolism and cellular redox and induces acute production of ROS with associated evidence of severe oxidative stress in proliferating T cells at above 5µM concentration. Shown to have potentiating effects on chemotherapeutic agents. |
| Molecular Formula | C15H18ClO4 . Na |
| Alias Names | (R)-(+)-Etomoxir Na; (R)-(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt |
| Product Type | Chemicals & Biochemicals |
| Purity | >98% |
| Shipping Information | RT |
| Size | 5 mg |
| Solubility | Soluble in water (5mg/ml), DMSO (5mg/ml), ethanol (1mg/ml) or DMF (5mg/ml). |
| Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Storage | -20°C, 4°C |
| Technical Specifications | Chemical. CAS: 828934-41-4. Formula: C15H18ClO4 . Na. MW: 297.8 . 23.0. . Irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1a) a mitochondrial enzyme involved in fatty acid beta-oxidation. CPR-1a on the outer face of the inner mitochondrial membrane, consequently prevents the formation of acyl carnitines, a step that is necessary for the transport of fatty acyl chains from the cytosol into the intermembrane space of the mitochondria, essential for the production of ATP from fatty acid oxidation. Fatty acid beta-oxidation (FAO) inhibitor. By regulating fatty acid oxidation it has hypoketonaemic, hypocholesteraemic and hypolipogenic effect, and the potential to affect ketogenesis, cholesterol synthesis and gluconeogenesis. Useful agent for immunometabolism research. Anticancer, antiobesity and antidiabetes agent. Increases food intake and reduces hepatic ATP/ADP ratio. Mitochondrial fatty acid oxidation may provide NADPH for defense against oxidative stress and prevent ATP loss and cell death. PPARalpha activator/agonist. Shows non-specific effects on oxidative metabolism and cellular redox and induces acute production of ROS with associated evidence of severe oxidative stress in proliferating T cells at above 5µM concentration. Shown to have potentiating effects on chemotherapeutics agents. |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
