Article No
AG-CR1-3560-M005
Specifications
| CAS No | 459789-99-2 |
| MW | 420.6 |
| Article No | AG-CR1-3560-M005 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Description | 6-ECDCA |
| Supplier | Adipogen Life Sciences |
| Format | Powder |
| Notes | Chemical. CAS: 459789-99-2. Formula: C26H44O4. MW: 420.6. Potent and selective FXR agonist (EC50= 99nM). Induces SHP in HSCs to suppress TIMP-1 expression. Apoptosis inducer. Protects against liver fibrosis development in rat in vivo. Displays anticholeretic activity in rat in vivo. Promotes preadipocyte differentiation. Regulates adipogenesis and insulin signaling in vivo. Inhibits vascular smooth muscle cell inflammation and migration.|Potent and selective farnesoid X receptor FXR agonist (EC50= 99nM) [1]. Induces SHP in HSCs to suppress TIMP-1 expression [2]. Apoptosis inducer [2]. Protects against liver fibrosis development in rat in vivo [2]. Displays anticholeretic activity in rat in vivo [3]. Promotes preadipocyte differentiation [4]. Regulates adipogenesis and insulin signaling in vivo [4]. Inhibits vascular smooth muscle cell inflammation and migration [5]. |
| Molecular Formula | C26H44O4 |
| Alias Names | 6alpha-Ethyl-chenodeoxycholic acid; 6-alpha-ECDC; Obeticholic acid; INT-747 |
| Product Type | Chemicals & Biochemicals |
| Purity | >95% |
| Research area | Metabolism |
| Shipping Information | BLUE ICE |
| Size | 5 mg |
| Solubility | Soluble in ethanol, methanol, or DMSO. Slightly soluble in water, dichloromethane and acetone. |
| Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Storage | -20°C, 4°C |
| Technical Specifications | Chemical. CAS: 459789-99-2. Formula: C26H44O4. MW: 420.6. Potent and selective FXR agonist (EC50= 99nM). Induces SHP in HSCs to suppress TIMP-1 expression. Apoptosis inducer. Protects against liver fibrosis development in rat in vivo. Displays anticholeretic activity in rat in vivo. Promotes preadipocyte differentiation. Regulates adipogenesis and insulin signaling in vivo. Inhibits vascular smooth muscle cell inflammation and migration. |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
