2'-Deoxy-5-formyl-cytidine

Article No AG-CR1-3531-M005
Product Type Chemicals & Biochemicals
Research Area Epigenetics
Format Powder
Size 5 mg

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Specifications

CAS No 137017-45-9
MW 255.2
Country Availability DK, EE, FI, IS, LT, LV, NO, SE
Data Sheet Link https://www.adipogen.com/productmanagement/resource/download/type/sheet/id/10980
Description 2'-Deoxy-5-formyl-cytidine
Supplier Adipogen Life Sciences
Notes Chemical. CAS: 137017-45-9. Formula: C10H13N3O5. MW: 255.2. Synthetic. Epigenetic base. A minor nucleotide found in DNA and produced by UV or γ-mediated oxidation of the nucleoside 5-Methyl-2'-deoxycytidine. This nucleoside derivative was found in embryonic stem cell DNA. Mutagenic and can induce 5-fC >> T transition mutation as well as the 5-fC >> A and 5-fC >> G transversion mutations during DNA synthesis, particularly in methylated CpG regions. Used in epigenetic research and important for cancer research.
Molecular Formula C10H13N3O5
Alias Names 5-Formyl-2’-deoxycytididine; 5-Formyl-dC; 5-fC; 5-FoC
Purity >98%
References Formation of 5-formyl-2'-deoxycytidine from 5-methyl-2'-deoxycytidine in duplex DNA by Fenton-type reactions and gamma-irradiation: N. Murata-Kamiya, et al.; Nucleic Acids Res. 27, 4385 (1999) | Synthesis and properties of oligonucleotides containing 5-formyl-2'-deoxycytidine: in vitro DNA polymerase reactions on DNA templates containing 5-formyl-2'-deoxycytidine: N. Karino, et al.; Nucleic Acids Res. 29, 2456 (2001) | The discovery of 5-formylcytosine in embryonic stem cell DNA: T. Pfaffeneder, et al.; Angew. Chem. Int. Edit. 50, 7008 (2011) | A.S. Synthesis of a DNA promoter segment containing all four epigenetic nucleosides: 5-Methyl-, 5-hydroxymethyl-, 5-formyl-, and 5-carboxy-2'-deoxycytidine: Schroeder, et al.; Angew. Chem. Int. Ed. 53, 315 (2014) | CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer; M. Zauri, et al.; Nature 524, 114 (2015)
Solubility Soluble in DMSO (10mg/ml) or water.
Storage -20°C
Technical Specifications Epigenetic base. A minor nucleotide found in DNA and produced by UV or γ-mediated oxidation of the nucleoside 5-Methyl-2'-deoxycytidine. This nucleoside derivative was found in embryonic stem cell DNA. Mutagenic and can induce 5-fC >> T transition mutation as well as the 5-fC >> A and 5-fC >> G transversion mutations during DNA synthesis, particularly in methylated CpG regions. Used in epigenetic research and important for cancer research.

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