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|Country Availability||DK, EE, FI, IS, LT, LV, NO, SE|
|Data Sheet Link||https://www.adipogen.com/productmanagement/resource/download/type/sheet/id/11289|
|Supplier||Adipogen Life Sciences|
|Notes||Potent and selective cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor. Apoptosis inducer. Potent glycogen synthase kinase (GSK-3alpha/beta) inhibitor.|
|References||CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases: K. Bettayeb, et al.; Oncogene 27, 5797 (2008) | Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice: H. Sallam, et al.; BMC Pharmacol. Toxicol. 14, 50 (2013) | Inhibition of NF-kappaB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes prosurvival stimuli to induce apoptosis in chronic lymphocytic leukemia cells: E. Cosimo, et al.; Clin. Cancer Res. 19, 2393 (2013)|
|Solubility||Soluble in DMSO or 100% ethanol.|
|Stability||Stable for at least 2 years after receipt when stored at -20°C.|
|Technical Specifications||Chemical. CAS: 294646-77-8. Formula: C24H29N7O. MW: 431.5. Potent and selective cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor. Apoptosis inducer. Potent glycogen synthase kinase (GSK-3alpha/beta) inhibitor.|
|Product Page Updated||2019-05-13T13:51:50.564Z|
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