AMI-1

Article No AG-CR1-0038-M025
Product Type Chemicals & Biochemicals
Research Area Inflammation
Format Powder
Size 25 mg

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Specifications

CAS No 160994-87-6 (xNa) | 134-47-4 (free base)
MW 592.4
Country Availability DK, EE, FI, IS, LT, LV, NO, SE
Data Sheet Link https://www.adipogen.com/productmanagement/resource/download/type/sheet/id/11292
Description AMI-1
Supplier Adipogen Life Sciences
Notes Chemical. CAS: 20324-87-2134-47-4 (free base). Formula: C21H12N2O9S2Na4. MW: 592.4. Potent, cell permeable and specific protein arginine N-methyltransferase 1 (PRMT1) inhibitor (IC50 = 8.8 µM). Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site. Blocks peptide substrate binding. HIV-1 RT polymerase inhibitor (IC50 = 5.0 µM).
Molecular Formula C21H12N2O9S2Na4
Alias Names Arginine N-methyltransferase inhibitor-1
Purity >99% (NMR)
References Small molecule regulators of protein arginine methyltransferases: D. Cheng, et al.; J. Biol. Chem. 279, 23892 (2004) | A novel mechanism for inhibition of HIV-1 reverse transcriptase: A.G. Skillman, et al.; Bioorg. Chem. 30, 443 (2002) | Inhibitory study of protein arginine methyltransferase 1 using a fluorescent approach: Y. Feng, et al.; BBRC 379, 567 (2009)
Solubility Soluble in water, 100% ethanol or DMSO.
Storage -20°C
Technical Specifications Potent, cell permeable and specific protein arginine N-methyltransferase 1 (PRMT1) inhibitor (IC50 = 8.8 µM). Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site. Blocks peptide substrate binding. HIV-1 RT polymerase inhibitor (IC50 = 5.0 µM).

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