AMI-1
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Specifications
| CAS No | 160994-87-6 (xNa) | 134-47-4 (free base) |
| MW | 592.4 |
| Country Availability | DK, EE, FI, IS, LT, LV, NO, SE |
| Data Sheet Link | https://www.adipogen.com/productmanagement/resource/download/type/sheet/id/11292 |
| Description | AMI-1 |
| Supplier | Adipogen Life Sciences |
| Notes | Chemical. CAS: 20324-87-2134-47-4 (free base). Formula: C21H12N2O9S2Na4. MW: 592.4. Potent, cell permeable and specific protein arginine N-methyltransferase 1 (PRMT1) inhibitor (IC50 = 8.8 µM). Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site. Blocks peptide substrate binding. HIV-1 RT polymerase inhibitor (IC50 = 5.0 µM). |
| Molecular Formula | C21H12N2O9S2Na4 |
| Alias Names | Arginine N-methyltransferase inhibitor-1 |
| Purity | >99% (NMR) |
| References | Small molecule regulators of protein arginine methyltransferases: D. Cheng, et al.; J. Biol. Chem. 279, 23892 (2004) | A novel mechanism for inhibition of HIV-1 reverse transcriptase: A.G. Skillman, et al.; Bioorg. Chem. 30, 443 (2002) | Inhibitory study of protein arginine methyltransferase 1 using a fluorescent approach: Y. Feng, et al.; BBRC 379, 567 (2009) |
| Solubility | Soluble in water, 100% ethanol or DMSO. |
| Storage | -20°C |
| Technical Specifications | Potent, cell permeable and specific protein arginine N-methyltransferase 1 (PRMT1) inhibitor (IC50 = 8.8 µM). Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site. Blocks peptide substrate binding. HIV-1 RT polymerase inhibitor (IC50 = 5.0 µM). |
Shipping info
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Product insert:
Datasheet