AMI-1
This product is not available for sale in your country. Please feel free to contact the help desk if you have any questions.
Specifications
| CAS No | 160994-87-6 (xNa) | 134-47-4 (free base) |
| MW | 592.4 |
| Country Availability | DK, EE, FI, IS, LT, LV, NO, SE |
| Data Sheet Link | https://www.adipogen.com/productmanagement/resource/download/type/sheet/id/11292 |
| Description | AMI-1 |
| Supplier | Adipogen Life Sciences |
| Notes | Potent, cell permeable and specific protein arginine N-methyltransferase 1 (PRMT1) inhibitor (IC50 = 8.8 µM). Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site. Blocks peptide substrate binding. HIV-1 RT polymerase inhibitor (IC50 = 5.0 µM). |
| Molecular Formula | C21H12N2O9S2Na4 |
| Alias Names | Arginine N-methyltransferase inhibitor-1 |
| Purity | >99% (NMR) |
| References | Small molecule regulators of protein arginine methyltransferases: D. Cheng, et al.; J. Biol. Chem. 279, 23892 (2004) | A novel mechanism for inhibition of HIV-1 reverse transcriptase: A.G. Skillman, et al.; Bioorg. Chem. 30, 443 (2002) | Inhibitory study of protein arginine methyltransferase 1 using a fluorescent approach: Y. Feng, et al.; BBRC 379, 567 (2009) |
| Solubility | Soluble in water, 100% ethanol or DMSO. |
| Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Storage | -20°C |
| Technical Specifications | Chemical. CAS: 20324-87-2134-47-4 (free base). Formula: C21H12N2O9S2Na4. MW: 592.4. Potent, cell permeable and specific protein arginine N-methyltransferase 1 (PRMT1) inhibitor (IC50 = 8.8 µM). Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site. Blocks peptide substrate binding. HIV-1 RT polymerase inhibitor (IC50 = 5.0 µM). |
| Product Page Updated | 2019-05-13T13:51:50.564Z |
Shipping info
The delivery time for this item is approximately 5-8 business days. If other deviations occur, this will be noted on the order confirmation or communicated via email. Please note, we do reserve the right to select the best packaging and shipping method in order to insure the stability of the product and allow efficient order tracking.
