1,5-Isoquinolinediol
This product is not available for sale in your country. Please feel free to contact the help desk if you have any questions.
Specifications
| CAS No | 5154-02-9 |
| MW | 161.2 |
| Country Availability | DK, EE, FI, IS, LT, LV, NO, SE |
| Data Sheet Link | https://www.adipogen.com/productmanagement/resource/download/type/sheet/id/11341 |
| Description | 1,5-Isoquinolinediol |
| Supplier | Adipogen Life Sciences |
| Notes | PARP-1 inhibitor. Neuroprotectant. Blocks nitric oxide-induced neuronal toxicity. Potent iNOS (inducible nitric oxide synthase/NOS II) inhibitor. Stimulates homologous recombination. |
| Molecular Formula | C9H7NO2 |
| Alias Names | 5-Hydroxy-1(2H)-isoquinolinone; 1,5-Dihydroxyisoquinoline |
| Purity | >98% (NMR) |
| References | Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase: M. Banasik, et al.; J. Biol. Chem. 267, 1569 (1992) | Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity: J. Zhang, et al.; Science 263, 687 (1994) | Inhibition of NOS-2 induction in LPS-stimulated J774.2 cells by 1, 5-isoquinolinediol, an inhibitor of PARP: R. Olszanecki, et al.; J. Physiol. Pharmacol. 57, 109 (2006) | 1,5-isoquinolinediol increases the frequency of gene targeting by homologous recombination in mouse fibroblasts: A. Semionov, et al.; Biochem. Cell Biol. 81, 17 (2003) |
| Solubility | Soluble in DMSO or methanol; insoluble in water. |
| Storage | +4°C |
| Technical Specifications | Chemical. CAS: 5154-02-9. Formula: C9H7NO2. MW: 161.2. PARP-1 inhibitor. Neuroprotectant. Blocks nitric oxide-induced neuronal toxicity. Potent iNOS (inducible nitric oxide synthase/NOS II) inhibitor. Stimulates homologous recombination. |
| Product Page Updated | 2019-01-09T14:34:57.552Z |
Shipping info
The delivery time for this item is approximately 5-8 business days. If other deviations occur, this will be noted on the order confirmation or communicated via email. Please note, we do reserve the right to select the best packaging and shipping method in order to insure the stability of the product and allow efficient order tracking.
