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|Country Availability||DK, EE, FI, IS, LT, LV, NO, SE|
|Data Sheet Link||https://www.adipogen.com/productmanagement/resource/download/type/sheet/id/11341|
|Supplier||Adipogen Life Sciences|
|Notes||Chemical. CAS: 5154-02-9. Formula: C9H7NO2. MW: 161.2. PARP-1 inhibitor. Neuroprotectant. Blocks nitric oxide-induced neuronal toxicity. Potent iNOS (inducible nitric oxide synthase/NOS II) inhibitor. Stimulates homologous recombination.|
|Alias Names||5-Hydroxy-1(2H)-isoquinolinone; 1,5-Dihydroxyisoquinoline|
|References||Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase: M. Banasik, et al.; J. Biol. Chem. 267, 1569 (1992) | Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity: J. Zhang, et al.; Science 263, 687 (1994) | Inhibition of NOS-2 induction in LPS-stimulated J774.2 cells by 1, 5-isoquinolinediol, an inhibitor of PARP: R. Olszanecki, et al.; J. Physiol. Pharmacol. 57, 109 (2006) | 1,5-isoquinolinediol increases the frequency of gene targeting by homologous recombination in mouse fibroblasts: A. Semionov, et al.; Biochem. Cell Biol. 81, 17 (2003)|
|Solubility||Soluble in DMSO or methanol; insoluble in water.|
|Technical Specifications||PARP-1 inhibitor. Neuroprotectant. Blocks nitric oxide-induced neuronal toxicity. Potent iNOS (inducible nitric oxide synthase/NOS II) inhibitor. Stimulates homologous recombination.|
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