(-)-Viriditoxin

Article No AG-CN2-0471-C500
Product Type Chemicals & Biochemicals
Research Area Cell Death
Format Powder
Size 500 µg

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Specifications

CAS No 1381782-08-6
MW 662.6
Country Availability DK, EE, FI, IS, LT, LV, NO, SE
Data Sheet Link https://www.adipogen.com/productmanagement/resource/download/type/sheet/id/11637
Description (-)-Viriditoxin
Supplier Adipogen Life Sciences
Notes Antibiotic. Exhibits broad activity against Gram-positive bacteria. Bacterial cell division protein FtsZ inhibitor (IC50=8.2µg/ml). Inhibits the GTPase activity of FtsZ in vitro (IC50=7.0µg/ml). Induces apoptosis and autophagy and inhibits cell growth at G2/M in human prostate cancer cells. Activates ATP hydrolysis and induces calcium sensitized swelling of rat liver mitochondria.
Molecular Formula C34H30O14
Alias Names (M)-Viriditoxin; SC-28762
Purity >98% (HPLC)
References Viriditoxin production by Aspergillus viridi-nutans and related species: E.B. Lillehoj & M.S. Milburn; Appl. Microbiol. 26, 202 (1973) | Metabolic products from Spicaria divaricata NRRL 5771: J. Jiu S. Mizuba; J. Antibiot. (Tokyo) 27, 760 (1974) | Viriditoxin induces swelling and atpase by activation of calcium transport in liver mitochondria: D.T. Wong & R.L. Hamill; BBRC 71, 332 (1976) | Discovery of a small molecule that inhibits cell division by blocking FtsZ, a novel therapeutic target of antibiotics: J. Wang, et al.; J. Biol. Chem. 278, 44424 (2003) | Second-Generation Synthesis of (-)-Viriditoxin: C.I. Grove & J.T. Shaw; Synthesis 2012, 362 (2012) | Viriditoxin regulates apoptosis and autophagy via mitotic catastrophe and microtubule formation in human prostate cancer cells: S. Kundu, et al.; Int. J. Oncol. 45, 2331 (2014) | A twist of nature - the significance of atropisomers in biological systems: J.E. Smyth, et al.; Nat. Prod. Rep. 32, 1562 (2015)
Solubility Soluble in DMSO or ethanol.
Source / Host fungi
Stability Stable for at least 2 years after receipt when stored at -20°C.
Storage -20°C
Technical Specifications Chemical. CAS: 1381782-08-6. Formula: C34H30O14. MW: 662.6. Isolated from fungus Aspergillus sp. Antibiotic. Exhibits broad activity against Gram-positive bacteria. Bacterial cell division protein FtsZ inhibitor (IC50=8.2µg/ml). Inhibits the GTPase activity of FtsZ in vitro (IC50=7.0µg/ml). Induces apoptosis and autophagy and inhibits cell growth at G2/M in human prostate cancer cells. Activates ATP hydrolysis and induces calcium sensitized swelling of rat liver mitochondria.
Product Page Updated 2019-05-13T13:51:50.564Z

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Source/Host:

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