Products ({{ products.totalElements }})
News & articles ({{ wpNewsAndArticles.total_posts }})
Blog entries ({{ wpBlogEntries.total_posts }})

{{ String(product.attributes.name) }} {{ String(product.attributes.productType) }} - NEW	{{ String(product.attributes.artNo) }}	{{ (String(product.attributes.sizeStr) != 'undefined') ? String(product.attributes.sizeStr) : '–' }}	Not available On Request {{ formatPrice(product.attributes.discountPrice.toString()) }} {{ formatPrice(product.attributes.price.toString()) }} {{ formatPrice(product.attributes.discountPrice.toString()) }} {{ formatPrice(product.attributes.price.toString()) }} Login for price

Full search results →

No products found

News {{ news.date \| formatDate }} #{{tag.name}}

No news & articles found

Full search results →

blog entry {{ blogEntry.date \| formatDate }}

No blog entries found

Full search results →

Vincristine . sulfate

Chemicals & Biochemicals

Make a customized order

Article No

AG-CN2-0446-M005

Size

5 mg

Shipping Information

Article No

AG-CN2-0446-M005

Size

5 mg

Specifications

CAS No	2068-78-2
MW	825.0 . 98.1
Article No	AG-CN2-0446-M005
Country Availability	SE, FI, DK, NO, IS, EE, LV, LT
Description	Vincristine . sulfate
Supplier	Adipogen Life Sciences
Format	Powder
Notes	Chemical. CAS: 2068-78-2. Formula: C46H56N4O10 . H2SO4. MW: 825.0 . 98.1. Synthetic. Originally isolated from Vinca rosea. Immunosuppressant. Anticancer compound. Chemotherapeutic agent. Depolymerizes microtubules and irreversibly blocks binding of tubulin to microtubule proteins. Apoptosis inducer and cell cycle inhibitor in G2/M phase. Autophagy inhibitor. Inhibits microtubule-mediated fusion of autophagosome with lysosme. Inducer of IL-1beta production. Activates alone and synergistically together with doxorubicin the NLRP3-inflammasome mediated processing of IL-1beta. Monoamine oxidase (MAO) inhibitor.\|Immunosuppressant. Anticancer compound. Chemotherapeutic agent. Depolymerizes microtubules and irreversibly blocks binding of tubulin to microtubule proteins. Apoptosis inducer and cell cycle inhibitor in G2/M phase. Autophagy inhibitor. Inhibits microtubule-mediated fusion of autophagosome with lysosme. Inducer of IL-1beta production. Activates alone and synergistically together with doxorubicin the NLRP3-inflammasome mediated processing of IL-1beta. Monoamine oxidase (MAO) inhibitor.
Molecular Formula	C46H56N4O10 . H2SO4
Alias Names	VCR; 22-Oxovincaleukoblastine; NSC 67574; Oncovin; Lilly 37231; Leucristine; Leurocristine; LS-228
Product Type	Chemicals & Biochemicals
Purity	>98%
Research area	Cell Death
Shipping Information	RT
Size	5 mg
Solubility	Soluble in water, DMSO or methanol.
Stability	Stable for at least 2 years after receipt when stored at +4°C.
Storage	4°C, RT
Technical Specifications	Chemical. CAS: 2068-78-2. Formula: C46H56N4O10 . H2SO4. MW: 825.0 . 98.1. Synthetic. Originally isolated from Vinca rosea. Immunosuppressant. Anticancer compound. Chemotherapeutic agent. Depolymerizes microtubules and irreversibly blocks binding of tubulin to microtubule proteins. Apoptosis inducer and cell cycle inhibitor in G2/M phase. Autophagy inhibitor. Inhibits microtubule-mediated fusion of autophagosome with lysosme. Inducer of IL-1beta production. Activates alone and synergistically together with doxorubicin the NLRP3-inflammasome mediated processing of IL-1beta. Monoamine oxidase (MAO) inhibitor.
Product Page Updated	2024-02-01T08:25:01.492Z

Documentation

Datasheet

MSDS

References

Suppression of immune response by Vincristine and Vinblastine: A.C. Aisenberg; Nature 200, 484 (1963) | Vinblastine and vincristine are inhibitors of monoamine oxidase B: J.K. Son, et al.; J. Med. Chem. 33, 1845 (1990) | Cell death induced by vincristine in the intestinal crypts of mice and in a human Burkitt's lymphoma cell line: B.V. Harmon, et al.; Cell Prolif. 25, 523 (1992) | Interaction of vinca alkaloids with tubulin: a comparison of vinblastine, vincristine, and vinorelbine: S. Lobert, et al.; Biochemistry 35, 6806 (1996) | Antimitotic natural products and their interactions with tubulin: E. Hamel; Med. Res. Rev. 16, 207 (1996) | Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death: M.V. Blagosklonny, et al.; Cancer Res. 57, 130 (1997) | Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle: A. Jordan, et al.; Med. Res. Rev. 18, 259 (1998) (Review) | The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review: L.G. Wang; Cancer Chemother. Pharmacol. 44, 355 (1999) (Review) | Vincristine-induced apoptosis in vivo in peripheral blood mononuclear cells of children with acute lymphoblastic leukaemia (ALL): E. Groninger, et al.; Br. J. Haematol. 111, 875 (2000) | Autophagy-mediated HMGB1 release antagonizes apoptosis of gastric cancer cells induced by vincristine via transcriptional regulation of Mcl-1: Z. Zhan, et al.; Autophagy 8, 109 (2012) | Autophagy and microtubules - new story, old players: R. Mackeh, et al.; J. Cell Sci. 126, 1071 (2013) (Review) | Production of IL-1beta by bone marrow-derived macrophages in response to chemotherapeutic drugs: synergistic effects of doxorubicin and vincristine: J. Wong, et al.; Cancer Biol. Ther. 15, 1395 (2014)

Shipping info

The delivery time for this item is approximately 5-8 business days. Read more