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Helenalin

Chemicals & Biochemicals

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Article No

AG-CN2-0435-C500

Size

500 ug

Shipping Information

Article No

AG-CN2-0435-C500

Size

500 ug

Specifications

CAS No	6754-13-8
MW	262.3
Article No	AG-CN2-0435-C500
Country Availability	SE, FI, DK, NO, IS, EE, LV, LT
Description	Helenalin
Supplier	Adipogen Life Sciences
Format	Powder
Notes	Anticancer compound. NF-kappaB inhibitor. Apoptosis inducer. Potent anti-inflammatory agent. Telomerase inhibitor. Anti-trypanosomal and antiprotozoal compound Antibiotic. Shows anti-proliferative effects in 3T3-L1 preadipocytes. Autophagy inducer.\|Chemical. CAS: 6754-13-8. Formula: C15H18O4. MW: 262.3. Isolated from Arnica chamissonis. Anticancer compound. NF-kappaB inhibitor. Apoptosis inducer. Potent anti-inflammatory agent. Telomerase inhibitor. Anti-trypanosomal and antiprotozoal compound Antibiotic. Shows anti-proliferative effects in 3T3-L1 preadipocytes. Autophagy inducer.
Molecular Formula	C15H18O4
Alias Names	Helenalin A; NSC 85236
Product Type	Chemicals & Biochemicals
Purity	>96%
Research area	Cell Death
Shipping Information	RT
Size	500 ug
Solubility	Soluble in ethanol or DMSO.
Stability	Stable for at least 2 years after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Storage	-20°C, 4°C
Substrate / Buffer	Soluble in ethanol or DMSO.
Technical Specifications	Chemical. CAS: 6754-13-8. Formula: C15H18O4. MW: 262.3. Isolated from Arnica chamissonis. Anticancer compound. NF-kappaB inhibitor. Apoptosis inducer. Potent anti-inflammatory agent. Telomerase inhibitor. Anti-trypanosomal and antiprotozoal compound Antibiotic. Shows anti-proliferative effects in 3T3-L1 preadipocytes. Autophagy inducer.
Product Page Updated	2024-02-01T08:25:01.492Z

Documentation

Datasheet

MSDS

References

Constituents of Helenium species.XIII. The structure of Helenalin and Mexicanin A: W. Herz, et al.; JACS 85, 19 (1963) | Antitumor agents. 21. A proposed mechanism for inhibition of cancer growth by tenulin and helenalin and related cyclopentenones: I.H. Hall, et al.; J. Med. Chem. 20, 333 (1977) | Inhibition of nucleic acid synthesis in P-388 lymphocytic leukemia tumor cells by helenalin and bis(helenalinyl)malonate in vivo: W.L. Williams Jr, et al.; J. Pharm. Sci. 77, 178 (1988) | Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB: G. Lyss, et al.; J. Biol. Chem. 378, 951 (1997) | The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65: G. Lyss, et al; J. Biol. Chem. 273, 33508 (1998) | Helenalin triggers a CD95 death receptor-independent apoptosis that is not affected by overexpression of Bcl-x(L) or Bcl-2: V.M. Dirsch, et al.; Cancer Res. 61, 5817 (2001) | Anti-trypanosomal activity of helenalin and some structurally related sesquiterpene lactones: T.J. Schmidt, et al.; Planta Med. 68, 750 (2002) | Induction of human leukemia HL-60 cell differentiation via a PKC/ERK pathway by helenalin, a pseudoguainolide sesquiterpene lactone: S.H. Kim, et al.; Eur. J. Pharmacol. 511, 89 (2005) | Potent inhibition of human telomerase by helenalin: P.R. Huang, et al.; Cancer Lett. 227, 169 (2005) | Novel effect of helenalin on Akt signaling and Skp2 expression in 3T3-L1 preadipocytes: C.A. Auld, et al.; BBRC 346, 314 (2006) | Helenalin reduces Staphylococcus aureus infection in vitro and in vivo: D. Boulanger, et al.; Vet. Microbiol. 119, 330 (2007) | Helenalin-mediated post-transcriptional regulation of p21(Cip1) inhibits 3T3-L1 preadipocyte proliferation: K.M. Fernandes, et al.; J. Cell Biochem. 105, 913 (2008) | Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms: C. Berges, et al.; Mol. Immunol. 46, 2892 (2009) | Helenalin bypasses Bcl-2-mediated cell death resistance by inhibiting NF-kappaB and promoting reactive oxygen species generation: R. Hoffmann, et al.; Biochem. Pharmacol. 82, 453 (2011) | NF-kappaB p65 repression by the sesquiterpene lactone, Helenalin, contributes to the induction of autophagy cell death: C.B. Lim, et al.; BMC Complement. Altern. Med. 12, 93 (2012) | Natural sesquiterpene lactones induce programmed cell death in Trypanosoma cruzi: a new therapeutic target?: V. Jimenez, et al.; Phytomedicine 21, 1411 (2014)

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